An Introduction to Physical Oncology: How Mechanistic Mathematical Modeling Can Improve Cancer Therapy Outcomes (Chapman & Hall/CRC Mathematical and Computational Biology)
| Author | : | |
| Rating | : | 4.83 (952 Votes) |
| Asin | : | 1466551348 |
| Format Type | : | paperback |
| Number of Pages | : | 204 Pages |
| Publish Date | : | 2013-08-13 |
| Language | : | English |
DESCRIPTION:
This multidisciplinary research effort has led to encouraging results towards a better understanding of different aspects of cancer biology and oncology, from quantitative understanding of tumor growth and progression to improved detection and the treatment of cancer. The work is at the forefront of the convergence between physical science and cancer research. D. It examines cancer growth and treatment outcomes in the context of physical and biological processes across microscopic and macroscopic scales. Seminal work by the authors and their collaborators from medicine, biology, engineering, mathematics, and physics discussed in this book includes the development of "master equations" from first principles to quantify penetration of free drugs and nanoparticles across tumor tissue, and relating these ideas to their potentia
The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. Physical oncology has the potential to revolutionize cancer research and treatment. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.